VYEPTI® patient relaxing in lawn chair.

Clinical Studies

VYEPTI may impact migraine days

Actor portrayal

Proven to reduce monthly migraine days in clinical studies

Study goal

How well VYEPTI works to prevent migraine attacks in the strict environment of a clinical study.

People in the study

1072 people with chronic migraine and 665 people with episodic migraine.

Dosing

People took either VYEPTI 100 mg, VYEPTI 300 mg, or placebo. No one in the study knew which dose they were taking.

What can people expect with VYEPTI?

People with chronic migraine

who averaged 16 migraine days a month taking VYEPTI* had an average of

People with episodic migraine

who averaged 9 migraine days a month taking VYEPTI* had an average of

8 fewer

migraine days a month

*VYEPTI 100 mg or 300 mg

4 fewer

migraine days a month

*VYEPTI 100 mg or 300 mg

Goal of the studies

How well VYEPTI works to prevent migraine attacks over 3 months
(1 dose) in the strict environment of a clinical study.

People in the studies

1072 people with chronic migraine and 665 people with episodic migraine.

Dosing

People received either VYEPTI 100 mg, VYEPTI 300 mg, or placebo. No one in the study knew which dose they were receiving.

People with chronic migraine

who averaged 16 migraine days a month receiving VYEPTI* had an average of

8 fewer

migraine days a month

vs 6 with placebo, over 3 months

*VYEPTI 100 mg or 300 mg

Chronic migraine is characterized by 15 or more headache days per month, with at least 8 of those being migraine days.

People with episodic migraine

who averaged 9 migraine days a month receiving VYEPTI* had an average of

4 fewer

migraine days a month

vs 3 with placebo, over 3 months

*VYEPTI 100 mg or 300 mg

Episodic migraine is characterized by 4 to 14 headache days per month, with at least 4 of those being migraine days.

""

In the same chronic migraine study, after receiving VYEPTI for 6 months (2 doses)*

Up to 40% of people who averaged 16 migraine days a month achieved

zero

migraine days

for a month or more

40% on VYEPTI 300 mg, 35% on VYEPTI 100 mg, and 22% on placebo had zero migraine days for a month or more.

*This analysis was not part of the original study plan and was initiated after the study ended, so we cannot make any firm conclusions based on these results.

28 days in a row.

Results of a 2-year clinical study in patients with chronic migraine

Study goal

Study the safety of VYEPTI 300 mg and other patient-reported results over 2 years.

People in the study

128 people with chronic migraine.

Dosing

Everyone in the study knew they were receiving VYEPTI 300 mg, which may have influenced the results.

Safety results were similar to the original clinical trials

""
""

more than 70%

felt overall migraine improvement over 2 years*

nearly 60%

felt engaged in life at 2 years

*Based on a question asking people how they feel about change in their overall migraine status, ranging from very much worse/much worse to much improved/very much improved. Improvement includes much improved or very much improved.

Based on a questionnaire developed to measure the disability headaches cause in people's lives. Results were measured by the number of disability days reported in the past 3 months. Engaged in life was defined to include little or no disability (0-5 disability days reported).

Adults pictured in images above are real VYEPTI patients who were compensated for their time. These patients did not participate in the study.

Study goal

Study the safety of VYEPTI 300 mg and other patient-reported results over 2 years.

People in the study

128 people with chronic migraine.

Dosing

Everyone in the study knew they were receiving VYEPTI 300 mg, which may have influenced the results.

Safety results were similar to the original clinical trials

""

more than 70%

felt overall migraine improvement over 2 years*

""

nearly 60%

felt engaged in life at 2 years

*Based on a question asking people how they feel about change in their overall migraine status, ranging from very much worse/much worse to much improved/very much improved. Improvement includes much improved or very much improved.

Based on a questionnaire developed to measure the disability headaches cause in people's lives. Results were measured by the number of disability days reported in the past 3 months. Engaged in life was defined to include little or no disability (0-5 disability days reported).

Adults pictured in images above are real VYEPTI patients who were compensated for their time. These patients did not participate in the study.

""

“Since I've been on VYEPTI, more migraine-free days have allowed me to make plans with my friends and my family, and I don't have to worry about being sick. I feel like I'm living the life I never had.”


Stephanie, VYEPTI patient

Individual results may vary. Stephanie was compensated for her time.

VYEPTI® patient ambassador Stephanie smiling.

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Take note

Daily life impact with VYEPTI

These survey results show how satisfied real people outside of a clinical setting are with VYEPTI in their day-to-day lives.

Start the conversation

Ask your doctor if VYEPTI could be a yep for you

Before your next appointment, create your own Doctor Discussion Guide with personalized responses specific to your concerns and experience with migraine.

IMPORTANT SAFETY INFORMATION
AND APPROVED USE

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

VYEPTI may cause serious side effects such as:

  • Allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.
  • High blood pressure. High blood pressure or worsening of high blood pressure can happen after receiving VYEPTI. Contact your healthcare provider if you have an increase in blood pressure.
  • Raynaud’s phenomenon. A type of circulation problem (Raynaud’s phenomenon) can worsen or happen after receiving VYEPTI. Contact your healthcare provider if you have symptoms such as your fingers or toes feeling numb, cool, or painful, or changing color from pale to blue to red.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you have high blood pressure; circulation problems in your fingers and toes; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions. These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

VYEPTI may cause serious side effects such as:

  • Allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.
  • High blood pressure. High blood pressure or worsening of high blood pressure can happen after receiving VYEPTI. Contact your healthcare provider if you have an increase in blood pressure.
  • Raynaud’s phenomenon. A type of circulation problem (Raynaud’s phenomenon) can worsen or happen after receiving VYEPTI. Contact your healthcare provider if you have symptoms such as your fingers or toes feeling numb, cool, or painful, or changing color from pale to blue to red.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you have high blood pressure; circulation problems in your fingers and toes; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions. These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information.