How does VYEPTI work?

VYEPTI is an aCGRP, a type of medication designed specifically for the prevention of migraine. aCGRPs are recommended by the American Headache Society (AHS) to be one of the first types of preventive migraine treatment prescribed. Calcitonin gene-related peptide, or CGRP, is a protein in the body thought to be a key cause of migraine, triggering attacks when it binds with its receptor. VYEPTI binds to CGRP, holding on tightly and stopping it from binding to its receptor.

How VYEPTI® Works: Designed to Help Prevent Migraine Attacks

What is VYEPTI?

VYEPTI is the 1st and only FDA-approved preventive treatment for migraine given as an intravenous (IV) infusion.

Gets right to work

As an IV infusion, 100% of the medication is delivered into your bloodstream, so it can get right to work.

Purposefully designed

VYEPTI was purposefully designed as an IV infusion to start working fast and last through month 3 after each infusion.

How VYEPTI works

VYEPTI is an aCGRP, a type of medication designed specifically for the prevention of migraine.

aCGRPs are recommended by the American Headache Society (AHS) to be one of the first types of preventive migraine treatment prescribed.

Calcitonin gene-related peptide, or CGRP, is a protein in the body thought to be a key cause of migraine, triggering attacks when it binds with its receptor
VYEPTI binds to CGRP, holding on tightly and stopping it from binding to its receptor

The relationship between your body’s response to the medication and how VYEPTI prevents migraine is not known.

CGRP movement in the body. VYEPTI in the bloodstream, blocking CGRP from binding to receptors.

CGRP
Receptor
VYEPTI

CGRP
Receptor
VYEPTI

The relationship between your body’s response to the medication and how VYEPTI prevents migraine is not known.

Curious about VYEPTI?

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Registered nurses are ready to answer VYEPTI questions and help ease concerns.

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“For 18 years, I’ve just existed. Now, I feel like I’m experiencing the world for the first time.”

Electra, VYEPTI patient

Individual results may vary. Electra was compensated for her time.

VYEPTI® patient ambassador Electra smiling.

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IMPORTANT SAFETY INFORMATION

AND APPROVED USE

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

VYEPTI may cause serious side effects such as:

Allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.
High blood pressure. High blood pressure or worsening of high blood pressure can happen after receiving VYEPTI. Contact your healthcare provider if you have an increase in blood pressure.
Raynaud’s phenomenon. A type of circulation problem (Raynaud’s phenomenon) can worsen or happen after receiving VYEPTI. Contact your healthcare provider if you have symptoms such as your fingers or toes feeling numb, cool, or painful, or changing color from pale to blue to red.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you have high blood pressure; circulation problems in your fingers and toes; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions. These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information.