Frequently Asked Questions (FAQs)

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Find answers to your questions about VYEPTI, how it works, side effects, support, and more.

What is VYEPTI?

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults. It is the 1st and only FDA-approved intravenous (IV) infusion for the preventive treatment of migraine. VYEPTI is given as a 30-minute IV infusion 4 times a year (every 3 months).

How does VYEPTI work?

VYEPTI is specifically designed to prevent migraine attacks.

  • Inside the body, there is a protein called calcitonin gene-related peptide, or CGRP
  • CGRP attaches to and activates specific receptors, which may play a role in migraine
  • VYEPTI binds to CGRP and prevents it from attaching to and activating the receptors

The relationship between your body’s response to the medication and how VYEPTI prevents migraine is not known.

What is an infusion?

An intravenous, or IV, infusion is designed to deliver medicine directly into the bloodstream, so the medication can circulate throughout the body during infusion and get right to work.

A subcutaneous injection is given under the skin, and the delivery of medication to the bloodstream is slower.

What are the benefits of treatment with VYEPTI?

VYEPTI is a powerful preventive treatment for migraine that’s proven to reduce monthly migraine days from the very first treatment. More people treated with VYEPTI had fewer monthly migraine days through Month 3 compared with placebo.

What are the most common side effects of VYEPTI?

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions. These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or does not go away. Please read the Important Safety Information below and read the VYEPTI Patient Information to understand all the possible side effects.

Could VYEPTI be right for me?

If you are looking for migraine prevention that’s delivered differently, talk with your healthcare provider to find out if treatment with VYEPTI may be right for you.

  • Create your own Doctor Discussion Guide and bring it to your next appointment to help you have a more meaningful conversation with your healthcare provider about your migraine treatment
  • If you still have questions about VYEPTI, enroll in VYEPTI GO® to chat 1-on-1 with a registered nurse standing by to help

What do I need to do to prepare for my 30-minute VYEPTI treatment?

There are a few things you can do to help prepare for your VYEPTI treatment, including:

Before: Enroll in VYEPTI GO to talk with a registered nurse for helpful information such as resources and tips to help you get started. Confirm where you're going to get your infusion and drink plenty of water on infusion day.

During: Relax and ask any questions you may have.

After: Make your next infusion appointment in 3 months and get back to your daily routine.

Where do I go to get an infusion?

You can receive VYEPTI at an infusion center, at your doctor's office, or in the convenience of your home. Use the VYEPTI Infusion Locator to find a location that works for you. Check with your healthcare provider if their office provides VYEPTI infusions or if you qualify for home infusion.

If you have questions about VYEPTI treatment, you can talk with a registered nurse by enrolling in the VYEPTI GO program.

Through VYEPTI CONNECT®, we can work with your doctor and insurance provider to confirm if the selected infusion location(s) are covered by your plan.

Can I get an infusion at my doctor’s office or at home?

You can receive a VYEPTI infusion treatment at an infusion center, at your doctor's office, or in the convenience of your home. Check with your healthcare provider to find out if their office provides VYEPTI infusions or ask your insurance provider if you qualify to receive VYEPTI from a registered nurse in the comfort of your home.

What if I have a migraine attack on the day of my VYEPTI infusion?

Some people in the VYEPTI clinical studies had migraine attacks on the day they received treatment. While there are no limitations of use with VYEPTI, if you have a migraine attack on the day of your scheduled VYEPTI infusion, talk with your healthcare provider.

Can VYEPTI be given to people who are pregnant or planning to become pregnant?

Before a person is given VYEPTI, they should tell their healthcare provider if they are pregnant or plan to become pregnant, or if they are breastfeeding or planning to breastfeed. Read the VYEPTI Important Safety Information.

What if I become pregnant while taking VYEPTI?

Notify your healthcare provider immediately if you become pregnant while taking VYEPTI. Read the VYEPTI Important Safety Information.

Can my primary care provider prescribe VYEPTI, or will I need to be referred to a specialist?

Although VYEPTI can be prescribed by any authorized healthcare provider, they may refer you to a migraine/headache specialist or a neurologist.

Is there a patient support program for VYEPTI?

With VYEPTI GO, you'll have access to a registered nurse who can answer questions about VYEPTI. If you're looking into details of your healthcare insurance coverage or finding treatment locations, talk to your healthcare provider about enrolling in VYEPTI CONNECT for informational support along your treatment journey.

Interested in talking 1:1 with someone who can tell you about their personal migraine experiences, including taking VYEPTI? Connect with a mentor through the Mentor Program.

Is there a way to save on the cost of VYEPTI?

The VYEPTI CONNECT Copay Assistance Program helps eligible people with commercial insurance pay as little as $0 every 3 months. Offer includes 100-mg and 300-mg doses. Eligibility criteria and program maximums apply. This offer is NOT available for people enrolled in Medicare, Medicaid, or any other government healthcare program. Please see the full Terms and Conditions. Interested in enrolling? Check your eligibility.

Offer includes up to $200 in administration out-of-pocket (OOP) fees per VYEPTI treatment. Additionally, the amount you pay may differ by healthcare provider. Terms and conditions apply.

My healthcare provider ordered VYEPTI through a specialty pharmacy. What does that mean, and what will I have to do?

If VYEPTI was ordered through a specialty pharmacy, you will need to complete these few steps to ensure that your prescription is filled and shipped to your selected infusion location.

What is migraine?

Migraine is more than just a bad headache; it’s a neurological disease that affects more than 39 million Americans. It is likely that you or someone you know suffers from migraine.

Symptoms can be different for everyone. Some people may have pain or discomfort, aphasia (trouble with speech), auras (including visual disturbance), be sensitive to light and sound, feel sick to their stomach, and/or vomit.

The number of migraine attacks each month can vary. Some people have 15 or more migraine days in a month. This can really impact quality of life—more than 90% of people are unable to work or live their lives normally during a migraine.

What is the difference between chronic and episodic migraine?

Chronic migraine is characterized by 15 or more headache days per month, with at least 8 of those being migraine days.

Episodic migraine is characterized by 4 to 14 headache days per month, with at least 4 of those being migraine days.

Are there signs that a migraine attack is going to occur?

Symptoms can be different for everyone. A migraine runs through different phases.

During the first phase, some patients may experience certain symptoms as early as 3 days before a migraine. This may allow patients to correctly predict migraine headache up to 12 hours before its onset.

Common symptoms experienced during this phase are:

  • Tiredness
  • Yawning
  • Mood changes
  • Muscle tenderness
  • Food cravings
  • Light sensitivity
  • Neck discomfort
  • Gastrointestinal issues
IMPORTANT SAFETY INFORMATION
AND APPROVED USE

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

VYEPTI may cause allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or you are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions.

These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

VYEPTI may cause allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or you are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions.

These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information.