Real people with
real VYEPTI stories

0:01 Migraine attacks make me feel helpless. They make me feel like I can’t attend to my family.

0:08 I believe that migraines took away days of me being able to be the mother that I wanted to be.

0:15 I was really interested in VYEPTI.

0:17 It is a 30-minute infusion four times a year. I was like, “Sign me up! Let’s try it!”.

0:23 It’s fast, powerful, and long-lasting, and it helps stop migraine attacks before they start.

0:28 After losing so many moments to migraine, I have more migraine-free days, and I feel more in control.

0:34 Living with fewer migraine attacks means I can be more present and enjoy things I want to do. I feel my kids have their mom back.

0:45 I’m able to be the person that I want to be for them.

0:49 Just talking about it makes me a little emotional.

0:52 There’s no words to describe how thankful I am for VYEPTI!

0:58 Please listen as we share important safety information about VYEPTI.

0:12 My name is Lealani, I'm a mother, I enjoy crafting and playing the violin, and I'm a Migraine Victor and this is my story.

0:24 I was 5 years old when I had my first migraine attack; they went undiagnosed until I was 18.

0:31 Migraine isn't just a headache; it's a full body experience–it affects everything.

0:37 For me, migraine are devastating physically. I get an aura.

0:45 For me, they’re bright neon colors, bright flashy lights and nauseating.

0:53 When I'm in a migraine attack, I will go to my room and I will close out all the lights, but it gets lonely being by yourself in the middle of a migraine attack.

1:06 It has caused me to lose jobs, it has caused me to not experience things with my family.

1:14 I almost missed my own wedding. There's not anything in my life that migraine hasn't touched.

1:22 Before VYEPTI, I tried everything from natural remedies to a multitude of prescriptions. Before VYEPTI, I could not write things on a calendar and expect to keep them there so I wrote things on sticky notes. I would have a migraine and have to cancel.

1:41 How I heard about VYEPTI getting approved is I watched some of the migraine message boards, and when I heard that VYEPTI did get approved, actually my children and I went out and we celebrated with dinner out.

2:11 Hi Lealani, so you’re here today to receive VYEPTI. As you know, this treatment will be given to you as an IV infusion, delivering the medication right into your bloodstream.

2:20 Great, I’m ready and excited to get this going.

2:23 Okay, let's get started. It's important to prepare for your infusion by making sure you are well hydrated, and if you are wearing sleeves, make sure they are loose enough to roll up above your elbows.

2:33 Side effects are possible. Allergic reactions such as rash, swelling of the face, lips, tongue, or throat, trouble breathing, hives, and redness in the face can occur. Common side effects are stuffy nose, scratchy throat, and allergic reactions.

2:50 If you start to have any symptoms during your infusion, including the ones I just mentioned, let me know right away.

3:08 Once the infusion starts, it will take about 30 minutes, so you can sit back, relax, you can use this time to read, or use your phone to check emails, or catch up on social media. Feel free to just take this time for yourself.

3:32 Looks good! We’re done.

3:34 That was fast, what do I need to do now?

3:36 Why don't you take a minute to get your things together and you can set up your next infusion appointment 3 months from now, then you're all set to go about your day.

3:47 Before my first infusion, I was a little bit nervous. But for me, it was easy and the 30 minutes went by really quickly.

3:59 It's fantastic to have a real person, like a nurse, get in contact with you and give you great tips about what to expect for your infusion date.

4:14 Since VYEPTI, I have the possibility of waking up without a migraine. And I know that I can do things. I know that I can open my curtains and let the sunshine in. Now, with VYEPTI, I can write things with a felt tip pen, I can play music.

4:38 Now, I feel hopeful, triumphant.

4:44 My family has a saying, “Darn it do it” and now I can.

0:11 I think I started having migraine attacks around the age of 14. I felt like the world was shutting in on me. The pain was debilitating.

0:22 My name is Lou and this is my migraine story.

0:26 I live in Florida. I have a kid, I have a husband. We’re a big sports family. Besides being competitive, it means we don’t quit.

0:32 I started at the age of 6 in softball and went all the way up through college on scholarship.

0:37 When I would play softball, I would get migraine attacks—the sounds of the bats, and the yelling and screaming of your teammates and the crowd.

0:47 You hear nothing but thumping and pain. I loved the sport so much that my love took over the hurt of the migraine. But it was miserable.

0:58 The older I got, my migraine attacks would get worse. I would probably have 14, 15...

1:04 ...a month, easily. When I would have my migraine attacks, my life was on hold. It would come out of nowhere.

1:13 It would start behind my left ear, like I had the tip of an icepick that would just tap on the back of my neck. I would always have to tap my forehead, that was the only time I would get relief.

1:25 The light sensitivity, the sound sensitivity. The intensity was unbearable at times. I couldn’t watch TV, I couldn’t cook, I couldn’t even drive.

1:35 It would be a huge strain on my family. They feel helpless. They can’t touch me or do anything to help me.

1:47 I saw doctors off and on my whole life, but they always treated my migraine attacks as just normal headaches.

1:56 They would tell me that it’s part of growing up and being a woman. So no one ever diagnosed me. Finally I just got to the point where I said I needed to go see a specialist.

2:05 When I first got diagnosed with migraine the burden was released—now what are we going to do about it?

2:11 Then this infusion was brought up. My doctor did great explaining to me what VYEPTI was.

2:18 With an IV infusion, it’s a direct hit to the bloodstream. It was 30 minutes and then I was able to leave and go about my day.

2:27 I saw fast results by the next day.

2:30 Since having more migraine-free days, I feel like a brand-new person, a new mom, a new wife.

2:37 I get to do things that I haven’t got to do in a long time, I get to be me.

2:46 Once I started on my VYEPTI treatment, my…

2:50 …husband Steve and my son Braylen saw a glow that they haven’t seen in years. They’re happy and relieved that I’m able to live again.

2:59 Before, everything had a trigger, everything. I didn’t get to go watch my son run track, because I couldn’t be outside in the light. That was heart-breaking.

3:08 To be able to do that now, and to have that smile on his face to see me on the sideline is a blessing.

3:16 Since having more migraine-free days, I can live my life more actively. I’ve been able to do more with my family, to go outside and do sports with my kid.

3:26 I’ve been able to have date nights with my husband, things I haven’t been able to do for years. I’ve got to live my life again.

3:36 You have to stay positive, you have to have that competitive fight to live. My story needs to be heard and let people know that there is hope.

0:12 I had such dreams. I wanted to have a great career, be an amazing mom. Experience life.

0:23 When I started having migraine, it stopped everything in its tracks. All I’ve known for 18 years now, is pain.

0:33 My name is Electra, and this is my migraine story.

0:37 I was a stay-at-home mom, brand-new baby, he was only about 2 weeks old, and that’s when my migraine began.

0:44 In the beginning, migraine was happening a couple of times a month. When I had my second kid, it was happening a couple of times a week at least.

0:58 Sometimes I felt like I was just in a constant migraine.

1:01 It starts with a sharp, stabbing pain in my head. The light hurts. Noises hurt. Smells. I get nauseous. You tense up. It affects my neck and my back.

1:15 I would end up curled in a ball. It was debilitating and it takes over my life. My kids never got to do extracurricular activities because I wouldn’t know if I could pick them up.

1:30 I’ve never had true friendships. I’ve just kind of been living day by day. I told myself I just can’t keep living like this, there has to be something that can help me.

1:49 I felt like everything else my doctors and neurologists were having me try, they weren’t getting rid of it.

1:57 They didn’t have any new suggestions as to what could help. And that’s when I found a study that would include migraine.

2:04 I was able to take part in the VYEPTI clinical trial. When they said I qualified for this infusion medication, I was really excited.

2:16 The infusion part didn’t bother me because I thought that having an infusion once every three months was a lot easier than having to remember to take a pill.

2:27 It only took 30 minutes and then it’s done with.

2:31 The next day when I woke up, the constant cloudiness in my head was gone.

2:39 I wanted to test out my triggers, so my sons planned a trip outdoors. We were outside for 6 hours and there was no pain.

2:52 It was a totally new experience. I didn’t ever remember feeling this way.

2:57 After the clinical trials, I tried other medications in the meantime but they didn’t give me that same feeling.

3:06 When I heard that VYEPTI got FDA approved, I was exhilarated.

3:18 I now knew that I could be around my triggers. I stopped carrying my rescue medicine.

3:25 I plan to travel. I’m trying new foods, I’m spending my time with my kids.

3:35 Before VYEPTI, I felt like I was just a figure and not an actual parent. Now every day I'm just trying to get to know my kids.

3:50 My oldest has moved off to college and I feel like I've missed so much with him.

3:58 I just want to experience life with them. I want us to laugh together, I want us to have adventures together, and now I can.

4:08 For 18 years, I just existed. Now, I feel like I’m experiencing the world for the first time.

0:07 VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults. Do not receive VYEPTI if you are allergic to eptinezumab-jjmr or any of the ingredients in VYEPTI. Please see the Important Safety Information throughout and at the end of this video.

0:24 Hello, welcome to the Power Shift video series, where we're going to have authentic conversations about issues impacting people living with migraine. We hope these discussions will inspire you to reclaim your power from migraine.

0:36 I'm Lindsey Arnold, a Lundbeck employee. I also live with migraine. I had my first migraine attack when I was six years old. As an adult, I've been prescribed VYEPTI, which is a prescription medicine for the preventive treatment of migraine in adults.

0:52 I'm joined by special guests today to discuss the VYEPTI infusion experience. We have Lou and Chanci here with us today, both people living with migraine who've been prescribed VYEPTI and Ana Gjurgevich, a family nurse practitioner who administers VYEPTI. So I would love to hear more about each of you. Chanci, why don't you start us off?

1:14 Hey, my name is Chanci. I am from southeast Mississippi. I was diagnosed with migraine about 10 years ago. I am a mom to two. I am a wife, I'm an artist and I'm in grad school and I was started on VYEPTI about two years ago.

1:36 You are a busy lady. A lot going on. Very accomplished. Lou, how about you?

1:44 Well, I don't know if I can compete. I have one kid, he is 15. I am originally from Charlotte, North Carolina. I live in Ocala, Florida. I have a husband. I work full time in neurology. I was started on VYEPTI about two years ago as well.

2:00 Great. Thank you for joining us today. And Ana, how about you?

2:04 So my name is Ana Gjurgevich and I'm a nurse practitioner at a university-based hospital in Southern California. I work in the neurology division and I specialize in headache and facial pain. I work alongside neurologists that are board certified in headache medicine, and together, we treat patients with migraines and some of those are on VYEPTI.

2:28 Thank you, Ana, and thanks for taking care of patients like us.

2:33 Absolutely.

2:35 Chanci, when you first learned about VYEPTI, where were you in your migraine journey? What was your life like and what did you think when you first heard about an infusion treatment for migraine?

2:47 Sure. I was experiencing more and more migraine attacks. I think I was up to over half of the month I was experiencing migraine attacks. I was having to take more and more acute migraine relief medications.

3:10 When my neurologist told me about VYEPTI and it being an infusion once every three months, I was excited. I was like, "Sign me up, I need this." That's where you have that hope and you're just like, "Yes, yes, this is going to be it." I was so excited. And for me, it didn't take me very long to get my infusion set up.

3:30 Absolutely.

3:31 And for me, it didn't take me very long to get my infusion set up.

3:38 That's great to hear. And it sounds like you were incredibly persistent to continue, you know, seeking a treatment that works for you, even when you were kind of going through this cycle of trying new things and still having, you know, migraine attacks really frequently, it sounds like.

3:57 Oh yeah, oh yeah.

3:58 So, good on you for continuing to go, continuing to move forward.

4:03 Absolutely. Always have to continue to move forward.

4:07 Lou, where were you when you heard about VYEPTI and how did you feel about the infusion experience?

4:17 Well, I found out when I moved to Florida, I was constantly just more or less, not necessarily misdiagnosed, but just thrown that I had headaches and it's something I have to live with being a woman and this is part of growing up and I wasn't satisfied with it. So when I moved to Florida, I saw a neurologist, I saw a specialist…

4:35 And finally he introduced me about two years ago to VYEPTI and I couldn't say yes to him quicker than I did my husband when we got married. So it was something I was super excited about trying.

4:48 That's great to hear that you were willing to give it a shot. And really, I hear from both of you that you were really persistent in your journey to finding something that worked for you. So, Ana, as a nurse practitioner who administers VYEPTI to your patients, can you tell us a little bit more about VYEPTI and the infusion process?

5:00 Definitely.

5:01 So, Ana, as a nurse practitioner who administers VYEPTI to your patients, can you tell us a little bit more about VYEPTI and the infusion process?

5:12 Yes, when I first bring up VYEPTI as a preventive treatment for migraine for my patients, I usually get that look of, oh, wow, there's an IV form of medication to treat migraines. And so I always explain to patients that VYEPTI is the first and only FDA approved IV treatment for migraine prevention in adults.

5:39 I explain the process of the medication is delivered in about 30 minutes, it's given by a healthcare professional.

5:46 We also always discuss risk and benefits with the medication.

5:51 And it's also important to let them know that the medication is in the bloodstream at a hundred percent once the treatment is complete.

6:00 What are some side effects that people should be looking out for after their infusion, Ana? I know everybody tolerates the medication a little bit differently.

6:10 Yes, of course. Some of the most common side effects include stuffy nose, a scratchy throat, and allergic reactions. So it's really important to talk to a provider about any questions you have about potential side effects and to report any adverse events.

6:29 And what next steps should somebody be taking after that first infusion since it's every three months?

6:37 So during their infusion, I like to check in on the patients to see if they have any questions, but the patients should always make their next appointment for three months…

6:48 and usually after the infusion you're free to go about your day as normal, you can go back to work or just relax.

6:57 So Chanci, could you tell me a little bit about what your infusion experiences have been like? You've had a few VYEPTI treatments now, so you're kind of a pro at this point.

7:08 So at my infusion center I get a recliner, I get a warm blanket, I feel very well taken care of. My infusion nurses are always right there. They're looking in on me, asking me if I need anything. It's a very nice experience. I feel safe, I feel secure and yeah.

7:36 It's great to hear you have had a good experience. I'm kind of jealous of the warm blanket. That sounds really nice. Lou, what have your first few infusions been like and do you have any tips for anybody going in for their first time?

7:53 It's 30 minutes, put my EarPods in, watch a movie, call it a day and breathe a little bit and then know that it's going to be better at the end of it. And there's nothing really to say that's overwhelming about it. It's great.

8:08 That's great to hear, Lou. It does sound like you're getting great care and it's nice that you're able to carve out that time for you. But Ana, I've heard there are more options to getting VYEPTI than just going into an infusion center. Could you tell me a little bit more about where people can get VYEPTI?

8:29 Yeah, there are multiple options. It's determined by the provider or the insurance and also location. So in my practice, we have an infusion center and some of our patients would prefer to come to the infusion center because they're comfortable with the staff. If they live far – we have patients that come like three hours away or even more – we would find a facility near their home and then set them up for an infusion there. We just find out if they administer VYEPTI there, send the prescription over and they infuse the order. And then if they want to do it in their own home, we set up home health for them if the insurance allows it. Yeah, so there's a lot of options.

9:20 Your voice is so nice that makes me want to come to California and you infuse me. It's so welcoming. You just have this calm, that's awesome. I'm glad people are going to get to see you. It makes them feel better.

9:32 We have the recliners, we have the warm blankets. We have snacks.

9:36 I’ve gotta catch Florida up.

9:38 But do you have the warm blankets?

9:40 Yeah, and snacks!

9:44 So Ana, as someone who administers VYEPTI and is seeing people come back every three months, how does it feel for you to see and hear about people who are embracing their life a little bit more and experiencing fewer migraine days?

10:02 Well, it's always so rewarding to be able to help them, this patient population.

10:09 Being able to see them during their infusion and then it allows me to observe their progress over time. And it makes me just, it's really happy to see positive outcomes. It's really a positive experience.

10:23 That is great to hear it has to be very rewarding. I know I'm lucky to get to see the same infusion nurse every time I go in for my appointment. So that's been nice to have that continuity. And she always makes sure to ask how I've been doing. So it's nice to get that relationship too. Chanci, can you tell me a little bit more about what you've been doing with fewer migraine attacks in your life?

10:55 With more migraine-free days, I feel more free. I can do things that I haven't been able to do in a very long time. For example, I had red wine

11:09 for the first time in over 10 years and I didn't get a migraine attack, which was unbelievable.

11:19 I'm not constantly worried that I'm going to have a migraine attack. I don't feel that looming presence that might, ooh, well, today or tomorrow might be the day to get one. You make sure you don't eat this and you make sure you don't drink that. So I'm not as worried about triggers, I'm not as worried as I was and I feel more free as a result.

11:49 And Lou, what have you been doing with more migraine-free days? How has this impacted your life?

11:55 With more migraine-free days, I feel like I have a life again. I'm able to do things that I wasn't able to do before. Go to soccer games, go outside, be in the sunlight, not have to wear sunglasses all the time. I go on dates with my husband. Things I haven't been able to do in years and it's given me this opportunity just to breathe, to live, and I can't be more thankful for that.

12:22 That's great to hear that you both are really getting to live and experience your lives more and feel better on a more regular basis.

12:35 Chanci, could you give me one power tip that you have for someone who might be going in for first infusion with VYEPTI?

12:43 I would definitely recommend dressing comfortably and wearing layers.

12:53 Yes, I think that's a really important one. You never know what the temperature is going to be and the nurse also has to have access to your arm of course. So it's good to make sure that you wear something a little bit flexible. Lou, what's a power tip that you've discovered through your infusions?

13:11 Bring a book, bring a tablet, live your life as if you would every day. Don't stop because you're in an infusion center. So if you use a tablet every day or you're on your phone or you do whatever, do that.

13:21 Chanci, if you had to describe your mindset shift, how your life has changed in one word, now that you've started your infusions with VYEPTI, how would you describe that journey or describe how you're feeling now?

13:40 In one word, I'm thankful.

13:44 Amen.

13:45 That’s a very good one.

13:46 That’s perfect.

13:48 And Lou, what's your one word to describe how you're feeling now?

13:53 So my one word would be hopeful. Hopeful has a lot of power in it. And to me, that's what it's about.

14:01 Wow, so inspiring. Thank you, Lou and Chanci, for spending some time with me and telling me a bit more about your experience and Ana, thank you so much for lending us your expertise for the evening and sharing your point of view.

14:16 Please stay tuned to listen to Important Safety Information for VYEPTI and visit VYEPTI.com to learn more about IV infusion for the preventive treatment of migraine.

14:27 Please listen as we share important safety information about VYEPTI.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

IMPORTANT SAFETY INFORMATION

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

VYEPTI may cause allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; if you have trouble breathing; hives; or redness in your face.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you are pregnant or plan to become pregnant, or you are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions.

These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the Prescribing Information and Patient Information at vyepti.com