VYEPTI safety in clinical studies

Less than 2% of more than 1100 people stopped receiving VYEPTI due to side effects in clinical studies. The most common side effects were:

Stuffy nose and scratchy throat (6–8%)
Allergic reactions (1–2%)

Long-term safety

Side effects were similar when the safety of VYEPTI 300 mg, given every 12 weeks, was tested over 2 years in an additional study of 128 adults with chronic migraine. Discontinuation due to side effects was 6%. Everyone in the study knew they were receiving VYEPTI, and it was not compared with placebo, both of which could have impacted the results.

What else you should know about possible side effects

VYEPTI can also cause serious side effects such as allergic reactions, constipation with serious complications, high blood pressure, and Raynaud's phenomenon (a type of circulation problem).

Get emergency help right away for rash; swelling of your face, lips, tongue, or throat; trouble breathing; hives; or facial redness. Contact your healthcare provider if you have constipation that is severe or associated with constant belly pain or swelling, vomiting, or bloating; or if you have an increase in blood pressure or your fingers or toes feel numb, cool, or painful, or change color from pale, to blue, to red.

These are not all the possible side effects of VYEPTI. Please read the Patient Information for more details. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Tell your healthcare provider if you become pregnant or plan to become pregnant.

“I feel great after my infusion. VYEPTI helps me go on with my life.”

Jennifer, VYEPTI patient

Individual results may vary. Jennifer was compensated for her time.

VYEPTI® patient ambassador Jennifer smiling.

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Getting ready for VYEPTI

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IMPORTANT SAFETY INFORMATION

AND APPROVED USE

Do not receive VYEPTI if you have a known allergy to eptinezumab-jjmr or its ingredients.

APPROVED USE

VYEPTI is a prescription medicine used for the preventive treatment of migraine in adults.

VYEPTI may cause serious side effects such as:

Allergic reactions. Call your healthcare provider or get emergency medical help right away if you have any of the following symptoms of an allergic reaction: rash; swelling of your face, lips, tongue, or throat; trouble breathing; hives; or redness in your face.
Constipation with serious complications. Severe constipation can happen. In some cases, people have been hospitalized. Contact your healthcare provider if you have severe constipation or constipation with severe or constant belly pain, vomiting, swelling of belly, or bloating.
High blood pressure. High blood pressure or worsening of high blood pressure can happen. Contact your healthcare provider if you have an increase in blood pressure.
Raynaud’s phenomenon. A type of circulation problem (Raynaud’s phenomenon) can worsen or happen. Contact your healthcare provider if you have symptoms such as your fingers or toes feeling numb, cool, or painful, or changing color from pale to blue to red.

Before starting VYEPTI, tell your healthcare provider about all your medical conditions, including if you have high blood pressure; circulation problems in your fingers and toes;
are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including any prescription and over-the-counter medicines, vitamins, or herbal supplements.

The most common side effects of VYEPTI include stuffy nose and scratchy throat, and allergic reactions. These are not all the possible side effects of VYEPTI. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the full Prescribing Information and Patient Information.